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Striker Mason Greenwood will begin Manchester United’s Europa League group game against Astana in Old Trafford on Thursday.
The 17-year-old has made four substitute appearances in the Premier League this year.
England under-21 defender Axel Tuanzebe will begin, alongside midfielder Fred and book goalkeeper Sergio Romero.
Winger Daniel James misses out after picking up a knock against Leicester.
Even the 21-year-old Welshman, who has scored three goals in five league matches this season, joins midfielder Paul Pogba, forward Anthony Martial and defender Luke Shaw about the injury list.
Midfielder Jesse Lingard has recovered from disease and is likely to be involved.
Greenwood had an impressive summertime for United, scoring in pre-season victories over Inter Milan and Leeds later making his debut in a 2-0 defeat to Arsenal in the Premier League in March.
He will start his first game of the year on Thursday and director Ole Gunnar Solskjaer claims he’s”matured in the last six months”.
“He’s still quite young. I remember the kid who only wanted to play with his mates at the under-18s,” explained Solskjaer. “Now he’s knocking on the door along with his appetite for football must be growing.
“I simply don’t want to put too much pressure on him. Mason’s among the top finishers I have played with a couple of decent ones and I’ve seen.
“When you’re 17, 18, 19 years old, another game is obviously the most significant one. It doesn’t matter how many you scored.
“There’ll probably be 11 Astana players living the dream – it’s but one of the biggest games of their professions – but I still need it to be a memorable one for our players as well.”
Tuanzebe made his debut in a 4-0 win over Wigan in the FA Cup at January 2017 and has made nine first-team looks in total for Manchester United.
However he has played only 1 minute in the Premier League this year, coming on as a late substitute in Saturday’s narrow victory over Leicester.
“It’s a part of the practice of growing. I remember my glimpses in the first team in 19 – it was not to be but today I’m 21 and things are starting to open up more. I know just where I need to be going,” explained Tuanzebe.
Solskjaer added:”In case you do not throw them in, you don’t know what you’ve got. I really don’t see any method of accomplishing so.
“I have always done it wherever I’ve been, that’s my view for a trainer, to provide a chance, an opportunity.”
Despite reaching the quarter-finals of the Champions League last season, United entered the Europa League following a sixth-place finish in the Premier League.
They won this competition in their look in 2016-17 and have never failed to go beyond the group stages.
It is the first time they come up against Kazakh champions Astana, that are competing in the Europa League for the fourth consecutive season.
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